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Sysmex XE-2100

XE-2100

  • Fluorescence flow cytometry for high quality haematology analysis, wide range of parameters and excellent WBC differential
  • Extremely fast with low turnaround times
  • Gold-standard technology for reticulocytes (RET, IRF, RET-He optional)
  • Valuable information with diagnostic impact - immature granulocytes (IG) and immature platelet fraction (IPF, optional)
  • Expandable as total laboratory solution and proactive user support with online quality control

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XE-2100 - Gold-standard results and diagnostics. Superb speed.

Our XE-2100 differential analyser is a great example of why we are global leaders in haematology. Its fluorescence flow cytometry analysis technology delivers accuracy and precision never achieved before. Because it's extremely fast, processing up to 150 samples per hour, you can deliver results more quickly and greatly enhance the productivity of your lab. That’s good news for patients, and good for your bottom line.

The accuracy and clinical utility of our instruments are renowned around the world. The XE-2100 is the first analyser with a standard 5-part differential plus NRBC count. High-quality standard parameters for red blood cells make it easier to detect and screen anaemia. And hydrodynamic focusing in the RBC/PLT channel delivers a red blood cell parameter profile and haematocrit values in line with the reference methods. This level of accuracy and versatility opens doors for more powerful clinical utility and better patient support.

Breakthrough technologies for remarkable accuracy

We’ve been producing haematology analysers for over 40 years, and this is one of our best. The most important matter in any laboratory is the ability to detect pathological samples. The XE-2100 combines various technologies to deliver previously unheard-of accuracy and reliability.

Its automated white blood cell differential technology will help you significantly reduce the number of smear reviews. Innovative fluorescence flow cytometry technology for white cell differentials delivers unique accuracy and precision never achieved before. And its complete parameter panel for screening red cell disorders is based on high-quality standard parameters for red blood cells.

The XE-2100 includes other breakthrough technologies, like hydrodynamic focusing in the RBC/PLT channels. This delivers a precise red blood cell parameter profile and haematocrit value that correlates perfectly with the ICSH reference methods. And since basophils are identified in a separate channel for rare event detection, the results offer high reproducibility.   

Fast and helpful

The XE-2100 reduces turnaround times to a real minimum and reaches impressive throughput rates. It delivers up to 150 samples per hour in the CBC+DIFF+NRBC profile and even total cell profiles are processed at rates of around 110 samples/h.

The XE-2100 is the first analyser with a standard 5-part differential plus true NRBC counting. The FDA (Food and Drug Administration), for instance, has confirmed excellent correlation to the reference method for the reportable Immature Granulocyte (IG) measurement. Since there is better differentiation between the subpopulations, your or your staff’s workload can be decreased significantly.

Thanks to its range of technologies, diagnostic security and throughput rate, the XE-2100 can help to improve the productivity and clinical utility and address the profitability of almost any laboratory.

Diagnostic utility
  • NRBC counting

The XE-2100 offers precise and accurate NRBC counting. Because it counts instead of flagging, it improves the accuracy of the WBC count and WBC differential count by using a separate channel and devoted reagent system. This is useful for newborns, and for a variety of blood cell disorders. You or your lab staff will have to spend less time behind the microscope as you can avoid the tedious correction of a WBC count by visual microscopy.

  • RET-He measurement

An increasing reticulocyte concentration determined by quantification indicates only that the bone marrow is starting to respond to its stimulation. It does not show whether the new reticulocytes are of normal size, nor does it address their haemoglobin content. You need to measure the ‘quality’, i.e. the HGB content of these cells, as well. The XE-2100 can measure the haemoglobinisation of reticulocytes (optional). This lets you derive haematological algorithms, which can be used to assess iron deficiency and monitor its treatment. You can differentiate, for example, between non-functional and functional iron deficiencies.

  • Two PLT detection methods (impedance and fluorescence)

In the majority of samples, platelets are counted accurately by the impedance method. In some pathological samples, such as those with large platelets or red cell fragments, the fluorescence count is given priority as it is more accurate as cell populations can be more clearly identified due to their RNA content. An automatic switching algorithm does this selection for you.

  • Immature reticulocyte fraction (IRF)

In the XE-2100, reticulocytes are fractionated according to their fluorescence intensity into three categories – low (LFR), medium (MFR) and high fluorescence reticulocytes (HFR) - representing different maturity stages. The IRF is the ratio of immature retics with medium and high fluorescence activity (MFR + HFR) to total reticulocytes. This parameter is proving valuable in predicting bone marrow suppression and the recovery of erythropoiesis.

  • A meaningful assessment of thrombopoietic bone marrow activity (IPF)

The immature platelet fraction (IPF%) is reported as a percentage of the total platelet count. It provides a rapid indication of the platelet production status. The number of reticulated platelets found in peripheral blood is an indication for the rate of thrombopoiesis. Reactive bone marrow delivers an increased value of reticulated platelets. This information lets diagnosticians distinguish whether thrombocytopenia is caused by bone marrow failure or an increased destruction or loss of platelets in the peripheral blood. Analysing the IPF% provides a second dimension of the platelet count.

  • Understanding haemopoietic system activity

In many clinical conditions, accurately determining the reticulocyte differential reveals initial results of a therapy’s success. For example, the XE-2100 delivers accurate and valuable IRF information that opens up new clinical areas for patient management. The red cell profile alongside the reticulocyte differential will help you better assess the erythropoietic system status.

The IMI channel can be used to provide HPC (Haematopoietic Progenitor Cells) counts (optional) quickly and reliably when monitoring patients undergoing peripheral blood stem cell harvesting by detecting even the lowest concentrations of myeloid precursors.

System Expandability
  • XE Twin System

The IPU (information-processing unit), a Windows-based user interface, can manage information from both a single XE-2100 and two XE-2100 by running the Twin Configuration Manager (TCM). You define the software screens and so adapt the user interface to the needs of your laboratory.

  • XE-Alpha N

Create a single tabletop instrument by combining the XE-2100 and an SP-1000i slide-maker/stainer via a conveyer system.

  • HST-N and EXPERTline

Thanks to its network interfaces, the XE-2100 can be included in laboratory automation.

Manage your information efficiently

Manage your information efficiently

The XE-2100’s intuitive software makes patient and sample information management significantly easier. All activities can now be carried out by staff of any level as defined in the system so you can enhance your flexibility.

To further simplify your daily QC results management, the use of XE-2100 and e-CHECK (XE) also lets you access SNCS IQAS Online, Sysmex’s international external quality assurance system.

This outstanding Internet-based external quality control service judges the performance of your analyser by each day comparing its quality control data to peer group data collected from other systems of the same type.

Tailor your XE-2100 ‒ include advanced clinical parameters

Tailor your XE-2100 ‒ include advanced clinical parameters

You can also tailor the XE-2100 to your very specific needs. Sysmex’s standard software, known as XE-PRO, improves the workflow flexibility and range of parameters. It covers areas of reagent management, QC data management, extended electronic data output and makes the device more flexible.

Importantly, you can also add modules that extend the range of parameters your XE-2100 can measure. These advanced clinical parameters include IG count, IPF, RET-He and HPC analysis .

Specifications

Specifications

Technologies

fluorescence flow cytometry: WBC DIFF, IG, NRBC, RET, IRF, PLT-O

DC sheath flow: RBC, HCT, PLT

RF/DC method: HPC

cyanide-free SLS method: HGB

 

Diagnostic parameters

WBC, RBC, HGB, HCT, MCV, MCH, MCHC, PLT, IG (%, #),

NEUT (%, #), LYMPH (%, #), MONO (%, #), EO (%, #), BASO (%, #),

NRBC (%, #), RDW-SD, RDW-CV, MPV, P-LCR, PDW, PCT, RET (%, #),

LFR, MFR, HFR, IRF, PLT-O

research parameter: OTHER (%, #)

 

Optional parameters

HPC, RET-He, IPF

 

Scattergrams

WBC differential channel scattergram

WBC/BASO channel scattergram

NRBC channel scattergram

IMI channel scattergram

RET channel scattergram

PLT-O scattergram

 

Throughput

stand-alone: 150 samples/h (max.) auto mode

twin configuration: 300 samples/h (max.) auto mode

 

Sample volume

130 μL/200 μL (open/closed mode)

40 μL for capillary mode

 

Data storage

10,000 samples incl. graphics

5,000 patients/1,000 orders

 

Quality control

20 QC files, 300 data points

1 XbarM file

optional: daily external QC IQAS Online

 

Interfaces

LIS, line printer (serial)

graphic printer (parallel)

network (gigabit Ethernet)

SUIT (Sysmex Universal Interface)

USB, memory drive

 

Options

XE-RET Master, XE-IPF Master and XE-HPC Master

 

Configurations

stand-alone (PIM), twin (TCM),

or module of Sysmex automation concepts

 

Dimensions/weights

w x h x d [mm]/[kg]

706 x 711 x 535/81 (main unit)

706 x 711 x 912/93 (main unit incl. sampler)

195 x 333 x 395/16 (pneumatic unit)

315 x 75 x 335/6 (IPU: information-processing unit)

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