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Haemostasis is the body’s physiological method of maintaining blood circulation. The combination of complex actions between the blood vessel, smallest blood cells (platelets) and specific proteins in the plasma stop bleeding if a blood vessel is damaged.
The mechanisms involved need a regulatory system to ensure a proper balance between the need to stop bleeding and causing a blockage in the vessel.
Those suffering from an imbalance in the haemostasis system can have a higher bleeding risk (haemophilia) or a higher risk of blockage of the blood vessels by undesired clot formation (thrombosis).
Through our analysers and other services, Sysmex has significant experience in helping doctors diagnose patients with haemostatic disorders or treating patients to prevent them bleeding or thrombosis. From basic to highly specialised tests, our analyser portfolio covers the needs of all kinds of laboratories.
When blood vessel walls are damaged, blood vessels contract to slow down the blood stream. The damaged cells from vessel’s inner wall (endothelium) trigger several processes, including the activation of platelets and the clotting mechanism. Activated platelets stick together (adhesion) and form complexes (aggregation) that result in the first haemostatic plug in the vessel wall to stop the bleeding. Activated platelets also form the surface for the clotting process.
Clotting (coagulation) occurs through the formation of a network of fibrin, which in turn is the result of many other so-called clotting factors being activated. The fibrin network and the haemostatic plug form a secure solution for stopping bleeding and give the body the opportunity to repair the blood vessel.