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Being diagnosed with haematologic malignancy actually happens either because the patient presents with certain symptoms or – as is becoming increasingly common – there are incidental findings during routine blood screening on modern haematology analysers. This white paper aims to describe how parameters of a complete blood count may reveal significant abnormalities and improve the incidental findings of suspected haematologic samples early on.
Chronic kidney disease (CKD) is a severe complication in context of various civilisation diseases, such as diabetes, hypertension, and obesity. With increasing treatment cost along the progression of CKD towards end-stage renal failure (ESRF) and the need for renal replacement therapies, CKD is not only a driver of premature mortality and diminished quality of life of affected individuals, but also puts significant burden on the society and healthcare expenditures. The early detection of kidney damage through a frequent screening of risk patients could help to fight the burden of CKD. Cost-efficient routine urinalysis data could play a vital role in providing valuable information for screening, diagnosing, and monitoring of renal disorders.
The fluorescence technology and channel-specific reagents of the XN-Series provide much more than just a cell count. Depending on their cell membrane composition, cells are perforated and labelled differently, disclosing information about the cells’ activity, maturity stage, and malignancy. This white paper sheds a light on how the XN measures cell functionality.
Once the analysis results have been technically validated and considered reliable, they can be looked at from a clinical angle to search for suspect results. The task of biomedical validation is to recognise abnormal or conspicuous quantita¬tive results. Based on the findings compiled by the GFHC, there is a new rule set implemented in Extended IPU looking at things such as cut-off values, assessment of previous values or additional patient information. Check out the recommendation from GFHC.
Urinary tract infections (UTI) belong to the most common bacterial infections and, though suspected cases often turn out to be negative, contribute to high laboratory workloads and empiric prescription of antibiotics, a main driver antimicrobial resistance (AMR). This white paper reviews the strengths of the UF-series in ruling-out UTI, supporting its diagnosis and potential applications to further optimise the UTI laboratory workflow, aiming to fight AMR.
This case study explains how the same lymphocytes react in two different complementary methods: fluorescence flow cytometry in the WPC channel of the XN-Series haematology analyser and multicolour immunophenotyping using the XF-1600 analyser. The haematology analyser detected a lymphocytosis and a suspect flag for ‘Abnormal Lympho?’. Subsequently, clinical flow cytometry was performed and the markers confirmed the diagnosis of a B-CLL in this patient.
The immature platelet count (IPF#) is a new haematological diagnostic parameter available from a routine blood laboratory test. Discover in this white paper how it can help you to evaluate the effectiveness of antiplatelet medication and forecast the risk of adverse cardiovascular events.
A patient case showing early detection of latent iron deficiency, that would not have been detected in a normal routine blood count or blood smear is described. A low RET-He (reticulocyte haemoglobin equivalent) value triggered a confirmatory test and lead to prompt treatment of the patient.