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This white paper intents to give an overview of the most common types of anaemia with a focus on how haematological parameters such as RET-He and other advanced RBC parameters help to distinguish different causes of anaemia. The white paper also summarises current guidelines and publications on advanced RBC parameters in order to help clinicians in choosing the appropriate treatment for the individual patient.
Haemostasis is a complex process that helps to keep the blood in a fluid state and prevent blood loss at the site of injury. While the intact endothelium of blood vessels has an anti-thrombogenic function that prevents blood coagulation, in the case of vessel wall damage, the exposed sub-endothelial components initiate the formation of a clot that will stop blood loss.
The detection of blast cells in the peripheral blood is considered extremely important, and great responsibility is placed on the investigating laboratory. As well as informa¬tion on the physiology, this SEED article describes the possible causes of the release of blast cells into the blood, the char¬acteristics by which they can be identified and how further diagnosis is carried out.
Besides the IG there is a distinct separation of an abnormal cell population with high fluorescence intensity above the monocyte and lymphocyte region. Highly fluorescent lymphocyte cells (HFLC) are observed in the DIFF channel of the Sysmex XE-series haematology analysers in an area of high fluorescence intensity.
The early differentiation of the underlying cause of canine anaemia is one of the biggest diagnostic challenges for veterinary clinicians. The reticulocyte count, together with the study of the different circulating degrees of maturity may allow a much more thorough and detailed assessment of each patient in the veterinary lab. In this preliminary study, reference ranges have been established for reticulocyte maturity fractions. Following the assessment of more than 150 anaemic patients, the Ecija-Mendoza diagram was created, a diagnostic tool that allows the differentiation between conditions caused by haemolysis, acute haemorrhage and anaemia due to dyserythropoiesis to allow the clinician to quickly form a suspected diagnosis.