FIT screening

Colorectal cancer (CRC) is one of the most frequently diagnosed cancers. The good news is that CRC incidence and mortality can be reduced significantly if detected early enough.

Faecal immunochemical tests (FIT) are non-invasive and can detect blood in stool invisible to the naked eye. Due to its simplicity, FIT is currently considered the best non-invasive test for CRC screening.

Invest a little time in your own health by taking the FIT to prevent or detect colon cancer early on.
For further information, please visit our ‘FIT for screening’ website


Reference Ranges – and what Sysmex can offer

Sysmex very frequently receives requests for reference ranges for the CBC parameters.

Of course we are glad to provide you with a selection of literature, but reference ranges from different studies are only conditionally transferable, depending on age, gender, ethnicity, etc.

For this reason, the individuals who served as the basis for the selected reference range should be as similar as possible to the patient population to whom the reference range is to be applied.

Currently, there are several scientific publications that provide information about the reference ranges for Sysmex analysers (see table below). These studies were performed mainly using X-Class haematology analysers and it can be seen that the reference ranges differ according to the populations involved. Therefore, published reference ranges from older analysers may be used on newer analysers, but only after validation. Since – as explained above – there are differences between haematological reference ranges from different populations, the information in the table may facilitate the selection of an appropriate reference range as an initial point for validation.

Examples of reference ranges for Sysmex analysers

First authorCitationAnalyserParametersPopulationFree online?
Hong et al.J Clin Lab Anal. 2014: early onlineXE-2100PLTHan Chineseno
Qiao et al.Clin Chem Lab Med. 2014: early onlineXE-2100CBCHan Chineseno
Ambayya et al. PLOS One 2014, 9(3): e91968XE-5000CBC+ researchMulti-ethnic Malaysianyes
Sehgal et al.Indian J Pathol Microbiol. 2013, 56(2): 120 XE-2100CBCIndianyes
El Graoui et al.Clin Lab. 2014, 60(3): 407XE-2100CBCMoroccanno
Pekelharing et al. Sysmex J Intl. 2010, 20(1):1 XE-5000 CBC + DIFF + RET Dutch     yes
Sysmex Corporation  XN-SeriesCBC, DIFF, RET, PLT-F Japanese     yes

Validation of Reference Ranges

Adopting a published reference range without validation is not permissible and can even be dangerous for patients. Its suitability as a reference must be examined in every case. To do this, the IFCC suggests the following procedure:

20 local reference samples are taken and compared with the reference range published elsewhere. If not more than 2 of the 20 samples are outside this range, it can be used.  If 3 - 4 samples are outside the reference range, a further 20 new samples must be taken. If not more than 2 of these 20 samples are outside the range, it can be used. If in the initial verification, 5 or more samples, or more than 2 of a repeated set of samples, are outside the published range, it is not suitable for use as a reference for local patients. The alternative is then a new survey or validation of another, different reference range.

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Sysmex parameters

XN-Series – Tailoring your haematology



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